Cyclobutanol → HCID 57799826, compound

HRID 2101186Notes

Reaction equation

HRID 2101186 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:14][C:15]2[CH:19]=[C:18]([CH3:20])[NH:17][N:16]=2)[N:3]=1.[CH:21]1([OH:25])[CH2:24][CH2:23][CH2:22]1>>[CH:21]1([O:25][C:2]2[C:11]3[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=3)[CH:5]=[C:4]([NH:14][C:15]3[CH:19]=[C:18]([CH3:20])[NH:17][N:16]=3)[N:3]=2)[CH2:24][CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 76218CyclobutanolHCID 57799674(1-chloro-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine

Product 1

HCID 57799826HCID 57799826, compound

Procedure

Similar procedure as described in example 10 was used, starting from (1-Chloro-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine and cyclobutanol to give (1-Cyclobutoxy-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine. LC-MS: m/e 325 (MH+).

Sources & evidence

ORD record
ord-db37d0cd93d04702a218274d8e1740f2
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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