(1-chloro-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine → HCID 23633501, compound

HRID 2101189Notes

Reaction equation

HRID 2101189 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:14][C:15]2[CH:19]=[C:18]([CH3:20])[NH:17][N:16]=2)[N:3]=1.[CH2:21]([Mg]Br)[CH:22]([CH3:24])[CH3:23]>>[CH2:21]([C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:14][C:15]2[CH:19]=[C:18]([CH3:20])[NH:17][N:16]=2)[N:3]=1)[CH:22]([CH3:24])[CH3:23]

Participants

3

Reactant 2

HCID 57799674(1-chloro-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amineHCID 178418816HCID 178418816, compound

Product 1

HCID 23633501HCID 23633501, compound

Procedure

Similar procedure as described in example 416 was used, staring from (1-Chloro-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine and isobutyl-magnesium bromide to give (1-Isobutyl-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine. LC-MS: m/e 311 (MH+).

Sources & evidence

ORD record
ord-312830ad20cd4345aab88681a5fb64a8
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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