HCID 57447918, compound → HCID 87678770, compound

Participants

Reaction Conditions

Reaction Steps

tert-butyl 2-({6-[(tert-butoxycarbonyl)amino]pyridin-3-yl}methyl)-3-[(4-methoxybenzyl)thio]-5-(3-{[methyl(2-phenylethyl)amino]carbonyl}phenyl)pentanoate (80 mg, 0.106 mmol) was dissolved in triethylsilane (0.4 mL) and trifluoroacetic acid (3.0 mL). The solution was heated to 60° C. for 1 h and was then concentrated. Purification of the residue by reversed-phase HPLC (C-8 column, linear gradient 20%→100% of MeCN in 5% aqueous MeCN containing 0.15% trifluoroacetic acid) gave the title diastereomeric compound as the trifluoroacetic salt (64 mg, 100%) after freeze-drying.

Provenance & Evidence