Acetic Acid → HCID 53417586, compound

HRID 2101233Notes

Reaction equation

HRID 2101233 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9](C([O-])=O)=[CH:10][CH:11]=[CH:12][CH:13]=2)=[CH:4][CH:3]=1.[C:17]([OH:20])(=O)C.S(Cl)([Cl:23])=O>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:17]([Cl:23])=[O:20])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 24386Thionyl ChlorideHCID 7023291HCID 7023291, compound

Product 1

HCID 53417586HCID 53417586, compound

Procedure

4′-Fluorobiphenyl carboxylate (10 mmol) was dissolved in thionyl chloride (30 mL) and refluxed for 3 hours. The mixture was poured into acetic acid (100 mL) and left to stand until bubbling ceased. Volatile components were removed under vacuum and the mixture left to crystallise overnight. The title compound was collected by filtration.

Workup

  1. temperaturerefluxed for 3 hours
  2. waitleft
  3. customuntil bubbling
  4. customVolatile components were removed under vacuum
  5. waitthe mixture left
  6. customto crystallise overnight
  7. filtrationThe title compound was collected by filtration

Sources & evidence

ORD record
ord-2b4a1b47ccfa4722918883162917e77e
Source dataset
uspto-grants-2009_08
Patent number
US07572825B2

Reaction notes

Loading…