Sodium Hydroxide → HCID 23158815, compound

HRID 2101258Notes

Reaction equation

HRID 2101258 reaction equation
[OH-].[Na+].[Br:3][C:4]1[C:8]([C:9](I)=[CH:10][C:11]([F:14])([F:13])[F:12])=[CH:7][S:6][CH:5]=1>C(O)C.O>[Br:3][C:4]1[C:8]([C:9]#[C:10][C:11]([F:13])([F:12])[F:14])=[CH:7][S:6][CH:5]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 74019576HCID 74019576, compound

Product 1

HCID 23158815HCID 23158815, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

Sodium hydroxide (1.2 g, 30 mmol) dissolved in a 50/50 mixture of ethanol and water was added to the product of Example 2. The reaction was stirred overnight at room temperature. The product was extracted with pentane and purified by distillation at 25° C., 300 mTorr. MS: m/z 256, 254, 236, 234, 206, 204, 175, 131, 106, 99, 69 1H-NMR: δ (ppm) 7.3 (d, 1), 7.7 (d, 1); 19F-NMR: δ (ppm) −50 (s, 3)

Workup

  1. extractionThe product was extracted with pentane
  2. distillationpurified by distillation at 25° C.

Sources & evidence

ORD record
ord-24883557b9c847a79623072cce3a1ea1
Source dataset
uspto-grants-2009_08
Patent number
US07572879B2

Reaction notes

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