5-chloro-6-fluoro-1H-indole-7-carboxylic acid → HCID 16678085, compound

HRID 2101265Notes

Reaction equation

HRID 2101265 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([C:12]([OH:14])=O)[C:10]=1[F:11])[NH:7][CH:6]=[CH:5]2.[F:15][C:16]([F:38])([F:37])[C:17]1[CH:18]=[C:19]([CH2:23][CH2:24][NH:25][CH2:26][C:27]2[CH:32]=[CH:31][C:30]([Si:33]([CH3:36])([CH3:35])[CH3:34])=[CH:29][CH:28]=2)[CH:20]=[CH:21][CH:22]=1>>[F:38][C:16]([F:15])([F:37])[C:17]1[CH:18]=[C:19]([CH2:23][CH2:24][N:25]([CH2:26][C:27]2[CH:32]=[CH:31][C:30]([Si:33]([CH3:35])([CH3:34])[CH3:36])=[CH:29][CH:28]=2)[C:12]([C:9]2[C:10]([F:11])=[C:2]([Cl:1])[CH:3]=[C:4]3[C:8]=2[NH:7][CH:6]=[CH:5]3)=[O:14])[CH:20]=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 251136475-chloro-6-fluoro-1H-indole-7-carboxylic acidHCID 57438505HCID 57438505, compound

Product 1

HCID 16678085HCID 16678085, compound

Procedure

5-Chloro-6-fluoro-1H-indole-7-carboxylic acid [2-(3-trifluoromethyl-phenyl)-ethyl]-(4-trimethylsilanyl-benzyl)-amide was prepared in analogy to example 1 from 5-chloro-6-fluoro-1H-indole-7-carboxylic acid and [2-(3-trifluoromethyl-phenyl)-ethyl]-(4-trimethylsilanyl-benzyl)-amine. MS (ISP) 547.3/549.4 (100/33) (M+H)+.

Sources & evidence

ORD record
ord-f47a40942eeb489eb7f3af802d896dc5
Source dataset
uspto-grants-2009_08
Patent number
US07572823B2

Reaction notes

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