Phenethylamine, m-trifluoromethyl- → HCID 57438505, compound

HRID 2101266Notes

Reaction equation

HRID 2101266 reaction equation
[CH3:1][Si:2]([CH3:12])([CH3:11])[C:3]1[CH:10]=[CH:9][C:6]([CH:7]=O)=[CH:5][CH:4]=1.[F:13][C:14]([F:25])([F:24])[C:15]1[CH:16]=[C:17]([CH2:21][CH2:22][NH2:23])[CH:18]=[CH:19][CH:20]=1>>[F:13][C:14]([F:24])([F:25])[C:15]1[CH:16]=[C:17]([CH2:21][CH2:22][NH:23][CH2:7][C:6]2[CH:9]=[CH:10][C:3]([Si:2]([CH3:12])([CH3:11])[CH3:1])=[CH:4][CH:5]=2)[CH:18]=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 104223Phenethylamine, m-trifluoromethyl-HCID 6375734-(Trimethylsilyl)benzaldehyde

Product 1

HCID 57438505HCID 57438505, compound

Procedure

[2-(3-trifluoromethyl-phenyl)-ethyl]-(4-trimethylsilanyl-benzyl)-amine was prepared in analogy to example 1 from 4-trimethylsilanyl-benzaldehyde and 2-(3-trifluoromethyl-phenyl)-ethylamine. MS (ISP): 352.3 (M+H)+. 1HNMR (CDCl3, 300 MHz): δ 7.48 (m, 4H), 7.39 (m, 2H), 7.27 (d, 2H), 3.81 (s, 2H), 2.80-3.00 (m, 4H), 0.26 (s, 9H).

Sources & evidence

ORD record
ord-be69abd15bab4f67b2eefcd19dd7e368
Source dataset
uspto-grants-2009_08
Patent number
US07572823B2

Reaction notes

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