HRID2101271

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID25113647

未命名化合物

结构：CC(C)[Si](C)(C)c1ccc(CNCCc2cccc(C(F)(F)F)c2)cc1

HCID57438508

未命名化合物

PRODUCTS

生成物

结构：CC(C)[Si](C)(C)c1ccc(CN(CCc2cccc(C(F)(F)F)c2)C(=O)c2c(F)c(Cl)cc3cc[nH]c23)cc1

HCID24780114

未命名化合物

PROCEDURE

实验过程

5-Chloro-6-fluoro-1H-indole-7-carboxylic acid [4-(isopropyl-dimethyl-silanyl)-benzyl]-[2-(3-trifluoromethyl-phenyl)-ethyl]-amide was prepared in analogy to example 1 from 5-chloro-6-fluoro-1H-indole-7-carboxylic acid and [4-(isopropyl-dimethyl-silanyl)-benzyl]-[2-(3-trifluoromethyl-phenyl)-ethyl]-amine. MS (ISP) 575.3/576.4/577.3 (100/46/40) (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-847787199de2400d93ed08c9aba7bb52
来源数据集: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07572823B2
来源说明: uspto-grants-2009_08

反应 SMILES

[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([C:12]([OH:14])=O)[C:10]=1[F:11])[NH:7][CH:6]=[CH:5]2.[CH:15]([Si:18]([CH3:40])([CH3:39])[C:19]1[CH:38]=[CH:37][C:22]([CH2:23][NH:24][CH2:25][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([C:33]([F:36])([F:35])[F:34])[CH:28]=2)=[CH:21][CH:20]=1)([CH3:17])[CH3:16]>>[CH:15]([Si:18]([CH3:40])([CH3:39])[C:19]1[CH:38]=[CH:37][C:22]([CH2:23][N:24]([CH2:25][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([C:33]([F:35])([F:34])[F:36])[CH:28]=2)[C:12]([C:9]2[C:10]([F:11])=[C:2]([Cl:1])[CH:3]=[C:4]3[C:8]=2[NH:7][CH:6]=[CH:5]3)=[O:14])=[CH:21][CH:20]=1)([CH3:16])[CH3:17]