7-(4-Chlorophenyl)-2-(4-(methylsufonyl)benzyl)-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3(2h)-one → 7-(4-Chlorophenyl)-2-(4-(ethylsulfonyl)benzyl)-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3(2h)-one

HRID 2101319Notes

Reaction equation

HRID 2101319 reaction equation
Cl[C:2]1C=CC(C2C=CN3C(=O)NN=C3C=2C2C=CN=CC=2)=CC=1.[Cl:24][C:25]1[CH:30]=[CH:29][C:28]([C:31]2[CH:36]=[CH:35][N:34]3[C:37](=[O:51])[N:38]([CH2:40][C:41]4[CH:46]=[CH:45][C:44]([S:47]([CH3:50])(=[O:49])=[O:48])=[CH:43][CH:42]=4)[N:39]=[C:33]3[C:32]=2[C:52]2[CH:57]=[CH:56][N:55]=[CH:54][CH:53]=2)=[CH:27][CH:26]=1>>[Cl:24][C:25]1[CH:30]=[CH:29][C:28]([C:31]2[CH:36]=[CH:35][N:34]3[C:37](=[O:51])[N:38]([CH2:40][C:41]4[CH:46]=[CH:45][C:44]([S:47]([CH2:50][CH3:2])(=[O:48])=[O:49])=[CH:43][CH:42]=4)[N:39]=[C:33]3[C:32]=2[C:52]2[CH:53]=[CH:54][N:55]=[CH:56][CH:57]=2)=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 160052367-(4-Chlorophenyl)-2-(4-(methylsufonyl)benzyl)-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3(2h)-oneHCID 577993927-(4-chlorophenyl)-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

Product 1

HCID 160052387-(4-Chlorophenyl)-2-(4-(ethylsulfonyl)benzyl)-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3(2h)-one

Procedure

The title compound was prepared by coupling 7-(4-chlorophenyl)-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one with the requisite benzyl halide in a manner analogous to that in which 7-(4-chlorophenyl)-2-(4-(methylsufonyl)benzyl)-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one was prepared. HPLC/MS: retention time=2.428 min, [M+H]+=505.

Workup

  1. customwas prepared

Sources & evidence

ORD record
ord-3c4140f224be4b008a72da5a950c8081
Source dataset
uspto-grants-2009_08
Patent number
US07572808B2

Reaction notes

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