7-(4-Chlorophenyl)-2-(4-(methylsufonyl)benzyl)-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3(2h)-one → 2-(4-(1h-Pyrazol-1-yl)benzyl)-7-(4-chlorophenyl)-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3(2h)-one

HRID 2101321Notes

Reaction equation

HRID 2101321 reaction equation
ClC1C=CC(C2C=CN3C(=O)[NH:15][N:16]=[C:10]3[C:9]=2[C:18]2C=CN=CC=2)=CC=1.[Cl:24][C:25]1[CH:30]=[CH:29][C:28]([C:31]2[CH:36]=[CH:35][N:34]3[C:37](=[O:51])[N:38]([CH2:40][C:41]4[CH:46]=[CH:45][C:44](S(C)(=O)=O)=[CH:43][CH:42]=4)[N:39]=[C:33]3[C:32]=2[C:52]2[CH:57]=[CH:56][N:55]=[CH:54][CH:53]=2)=[CH:27][CH:26]=1>>[N:16]1([C:44]2[CH:45]=[CH:46][C:41]([CH2:40][N:38]3[C:37](=[O:51])[N:34]4[CH:35]=[CH:36][C:31]([C:28]5[CH:29]=[CH:30][C:25]([Cl:24])=[CH:26][CH:27]=5)=[C:32]([C:52]5[CH:57]=[CH:56][N:55]=[CH:54][CH:53]=5)[C:33]4=[N:39]3)=[CH:42][CH:43]=2)[CH:10]=[CH:9][CH:18]=[N:15]1

Participants

3

Reactant 2

HCID 160052367-(4-Chlorophenyl)-2-(4-(methylsufonyl)benzyl)-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3(2h)-oneHCID 577993927-(4-chlorophenyl)-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

Product 1

HCID 160053122-(4-(1h-Pyrazol-1-yl)benzyl)-7-(4-chlorophenyl)-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3(2h)-one

Procedure

The title compound was prepared by coupling 7-(4-chlorophenyl)-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one with the requisite benzyl halide in a manner analogous to that in which 7-(4-chlorophenyl)-2-(4-(methylsufonyl)benzyl)-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one was prepared. HPLC/MS: retention time=2.72 min, [M+H]+=479.

Workup

  1. customwas prepared

Sources & evidence

ORD record
ord-d86d61d395a040e2b97e00efbe55762e
Source dataset
uspto-grants-2009_08
Patent number
US07572808B2

Reaction notes

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