Pyrazole → HCID 16005346, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-((5-bromopyridin-2-yl)methyl)-7-(4-chlorophenyl)-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one (29.6 mg, 0.06 mmol), pyrazole (22.5 mg, 0.33 mmol), copper (I) iodide (8 mg, 0.042 mmol), potassium carbonate (25 mg, 0.18 mmol) and N,N-dimethylethylenediamine (5.3 mg, 0.06 mmol) in 1 mL toluene was heated at 110° C. under argon for 20 h. The reaction mixture was diluted with EtOAc, washed with water, brine, dried (Na2SO4) and concentrated. The crude product was purified by preparative reverse phase HPLC (with TFA) to isolate 1.3 mg of the title compound as a yellow solid. HPLC/MS: retention time=2.44 min, [M+H]+=480.

Provenance & Evidence