6-(2-chlorophenyl)-7-(4-chlorophenyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one → 6-(2-chlorophenyl)-7-(4-chlorophenyl)-2-((2-methyl-6-(trifluoromethyl)pyridin-3-yl)methyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

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Reaction Steps

The title compound (25 mg, 47% yield) as an off-white solid was prepared from 6-(2-chlorophenyl)-7-(4-chlorophenyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one (36 mg, 0.1 mmol) and 3-(chloromethyl)-2-methyl-6-(trifluoromethyl)pyridine (31 mg, 0.15 mmol) in a manner analogous to that in which 8-bromo-7-(4-chlorophenyl)-5-methyl-2-((2-methyl-6-(trifluoromethyl)pyridin-3-yl)methyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one was prepared. HPLC/MS: retention time=4.30 min, [M+H]+=529.1.

Provenance & Evidence