1,2,3,4-Tetrahydroquinoline → 3-Methoxy-6-(tetrahydroquinoline-1-sulfonyl)-pyridazine

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-fluorosulfonyl-6-methoxypyridazine (2 mmol, 384 mg) and tetrahydroquinoline (4 mmol, 532 mg) was heated at 140° C. for two hours. The reaction mixture was cooled, extracted with EtOAc (20 mL), and the EtOAc extract was dried, filtered and evaporated to obtain 3-methoxy-6-(tetrahydroquinoline-1-sulfonyl)-pyridazine (73%, 451 mg).

Provenance & Evidence