Thionyl Chloride → chloromethyl-1-(3,5-dichlorobenzyl)-1H-imidazole hydrochloride

Participants

Reaction Steps

[1-(3,5-Dichloro-benzyl)-1H-imidazol-2-yl]-methanol (1.7 g, 6.63 mmol) was dissolved in chloroform (16 mL) and diluted with thionyl chloride (2.9 mL, 40 mmol). The reaction was warmed to reflux. After 4 h, the reaction was concentrated to yield 1.95 g of 2-chloromethyl-1-(3,5-dichlorobenzyl)-1H-imidazole hydrochloride as a pale yellow solid (95%).

Provenance & Evidence