Ether hydrochloride → HCID 57801509, compound

Participants

Reaction Steps

{2-[[1-(3,5-dichloro-benzyl)-1H-imidazol-2-ylmethyl]-(3-fluoro-benzyl)-amino]-ethyl}-carbamic acid tert-butyl ester, (see Example 6) (455 mg, 0.899 mmol) was dissolved in MeOH (7 mL) and treated with 4N HCl/ether (2 mL). The solution was stirred at ambient temperature for 4 h. then heated to 40° C. for 3 h. The solvent was evaporated in vacuo providing N1-[1-(3,5-dichloro-benzyl)-1H-imidazol-2-ylmethyl]-N1-(3-fluoro-benzyl)-ethane-1,2-diamine (341 mg, 93%). ESI MS m/z 407 [C20H21Cl2FN4+H]+.

Provenance & Evidence