Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2-Nitroimidazole | HCID 10701 | — |
| Reactant | 1-(Bromomethyl)-3,5-dichlorobenzene | HCID 12583978 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 57801503 | HCID 57801503 | 91% |
Reaction Steps
To a solution of 2-nitroimidazole and 1-bromomethyl-3,5-dichloro-benzene in anhydrous DMSO was added Na2CO3. The reaction mixture was heated to 60° C. for 6 h. The reaction mixture was then diluted with EtOAc and washed with water (×4). The organic phase was dried over Na2SO4 and concentrated. The resulting residue was purified by silica gel prep TLC using 98:2 CH2Cl2:MeOH to afford 1-(3,5-dichloro-benzyl)-2-nitro-1H-imidazole (0.66 g, 91%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07572921B2 |
|---|
| Source dataset | uspto-grants-2009_08 |
|---|
| ORD ID | ord-7fce3a7e46be437c9c7c5575df745a31 |
|---|
| Source note | uspto-grants-2009_08 |
|---|
