Trifluoroacetic acid → HCID 11951963, compound

Participants

Reaction Steps

To a solution of [1-(3,5-dichloro-benzyl)-1H-imidazol-2-yl]-(4-fluoro-benzyl)-carbamic acid tert-butyl ester in CH2Cl2 was added trifluoroacetic acid. The reaction solution was stirred at room temperature for 3 h. When all the starting material was consumed, the mixture was diluted with CH2Cl2 and washed with water. The organic phase was dried over Na2SO4 and concentrated. The resulting residue was purified by silica gel preparative TLC using CH2Cl2:MeOH 95:5 as an eluent to afford the title compound (24 mg, 63%); LCMS m/z 350 [C17H14Cl2FN3+H]+.

Provenance & Evidence