5-Bromo-2-oxindole → HCID 67280932, compound

HRID 2101552Notes

Reaction equation

HRID 2101552 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[CH2:12]([N:14]([CH2:29][CH3:30])[CH2:15][CH2:16][CH2:17][NH:18][C:19]([C:21]1[NH:22][C:23]([CH:27]=O)=[C:24]([CH3:26])[CH:25]=1)=[O:20])[CH3:13]>>[CH2:29]([N:14]([CH2:12][CH3:13])[CH2:15][CH2:16][CH2:17][NH:18][C:19]([C:21]1[NH:22][C:23]([CH:27]=[C:5]2[C:4]3[C:8](=[CH:9][CH:10]=[C:2]([Br:1])[CH:3]=3)[NH:7][C:6]2=[O:11])=[C:24]([CH3:26])[CH:25]=1)=[O:20])[CH3:30]

Participants

3

Reactant 2

HCID 6111935-Bromo-2-oxindoleHCID 9835057HCID 9835057, compound

Product 1

HCID 67280932HCID 67280932, compoundYield 8.7%

Procedure

5-Bromo-1,3-dihydroindol-2-one (0.16 g, 0.75 mmol) was condensed with 5-formyl-4-methyl-1H-pyrrole-2-carboxylic acid (3-diethylaminopropyl)amide (0.2 g, prepared by method C) to give 30 mg (8%) of the title compound as an orange solid.

Sources & evidence

ORD record
ord-c57910a537f4448aa5140ee772f13487
Source dataset
uspto-grants-2009_08
Patent number
US07572924B2

Reaction notes

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