5-Bromo-2-oxindole → HCID 67280955, compound

HRID 2101555Notes

Reaction equation

HRID 2101555 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[CH2:12]([N:14]([CH2:28][CH3:29])[CH2:15][CH2:16][N:17]([CH3:27])[C:18]([C:20]1[NH:21][C:22]([CH:25]=O)=[CH:23][CH:24]=1)=[O:19])[CH3:13]>>[CH2:28]([N:14]([CH2:12][CH3:13])[CH2:15][CH2:16][N:17]([CH3:27])[C:18]([C:20]1[NH:21][C:22]([CH:25]=[C:5]2[C:4]3[C:8](=[CH:9][CH:10]=[C:2]([Br:1])[CH:3]=3)[NH:7][C:6]2=[O:11])=[CH:23][CH:24]=1)=[O:19])[CH3:29]

Participants

3

Reactant 2

HCID 6111935-Bromo-2-oxindoleHCID 86586195HCID 86586195, compound

Product 1

HCID 67280955HCID 67280955, compoundYield 55%

Procedure

5-Bromo-1,3-dihydroindol-2-one (212 mg, 1 mmol) was condensed with 5-formyl-1H-pyrrole-2-carboxylic acid (2-diethylaminoethyl)methylamide to give 246 mg (55%) of the title compound.

Sources & evidence

ORD record
ord-9d48b3d09b6d4c8cb6e77a32373fe520
Source dataset
uspto-grants-2009_08
Patent number
US07572924B2

Reaction notes

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