5-Bromo-2-oxindole → HCID 67282757, compound

HRID 2101576Notes

Reaction equation

HRID 2101576 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[N:12]1([CH2:17][CH2:18][NH:19][C:20]([C:22]2[C:26]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[C:25]([CH:33]=O)[NH:24][C:23]=2[CH3:35])=[O:21])[CH2:16][CH2:15][CH2:14][CH2:13]1>>[N:12]1([CH2:17][CH2:18][NH:19][C:20]([C:22]2[C:26]([C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)=[C:25]([CH:33]=[C:5]3[C:4]4[C:8](=[CH:9][CH:10]=[C:2]([Br:1])[CH:3]=4)[NH:7][C:6]3=[O:11])[NH:24][C:23]=2[CH3:35])=[O:21])[CH2:13][CH2:14][CH2:15][CH2:16]1

Participants

3

Reactant 2

HCID 6111935-Bromo-2-oxindoleHCID 86586205HCID 86586205, compound

Product 1

HCID 67282757HCID 67282757, compoundYield 27%

Procedure

5-Bromo-1,3-dihydroindol-2-one (44 mg, 0.21 mmol) was condensed with 5-formyl-2-methyl-4-phenyl-1H-pyrrole-3-carboxylic acid (2-pyrrolidin-1-ylethyl)amide (70 mg, prepared in the same manner as the isopropyl analog, above) to give 0.03 g (27%) of the title compound as a yellow solid.

Sources & evidence

ORD record
ord-72228e4fe3824150ba8bc38a4f8ef1a7
Source dataset
uspto-grants-2009_08
Patent number
US07572924B2

Reaction notes

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