HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2101583Generated: October 30, 2026
Ethyl orthoformate → ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate
https://huagongshe.com/reaction/2101583
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | 2-Tert-butyl 4-ethyl 3,5-dimethyl-1h-pyrrole-2,4-dicarboxylate | HCID 4347660 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate | HCID 137485 | 64% |
Reaction Steps
A mixture of 2-tert-butyloxycarbonyl-3,5-dimethyl-4-ethoxycarbonylpyrrole and triethyl orthoformate (1.5 equiv.) in trifluoroacetic acid was stirred at 15° C. for 1 hour. The reaction was concentrated and the residue was purified to give (64%) 2,4-dimethyl-3-ethoxycarbonyl-5-formylpyrrole as yellow needles.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07572924B2 |
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| Source dataset | uspto-grants-2009_08 |
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| ORD ID | ord-9b1c8e4511a14dc7bae8fb9bbe921bed |
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| Source note | uspto-grants-2009_08 |
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