tert-Butyl 4-nitro-1H-indazole-1-carboxylate → tert-Butyl 4-amino-1H-indazole-1-carboxylate

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Reaction Steps

1,1-Dimethylethyl 4-nitro-1H-indazole-1-carboxylate (1.2 g) was dissolved in ethanol (150 ml) and stirred with 10% palladium on carbon (0.24 g) under an atmosphere of hydrogen (1 atmosphere pressure) for 18 h. The solution was filtered through a pad of celite and the filtrate concentrated in vacuo to give the title compound as a yellow-orange solid (1.03 g).

Provenance & Evidence