Cyclohexyl isocyanate → 4,5-bis(4-chlorophenyl)-N-cyclohexyl-1H-imidazole-2-carboxamide

Participants

Reaction Steps

Using essentially the same procedure as Example 25, Step B-C, but using cyclohexyl isocyanate (0.027 mL, 0.21 mmol) in Step B, 4,5-di-(4-chlorophenyl)-1-(2-(trimethylsilyl)ethoxymethyl)imidazole (36 mg, 0.086 mmol) from Example 25, Step A was converted to the SEM intermediate and then to the title compound with TBAF.

Provenance & Evidence