Cycloheptylamine → HCID 10116471, compound

HRID 2101727Notes

Reaction equation

HRID 2101727 reaction equation
[CH:1]1([NH2:8])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:9][C:10]1[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:11]=1[C:17]1[N:18]=[C:19]([C:30](OCC)=[O:31])[N:20]([CH3:29])[C:21]=1[C:22]1[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=1>>[CH:1]1([NH:8][C:30]([C:19]2[N:20]([CH3:29])[C:21]([C:22]3[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=3)=[C:17]([C:11]3[CH:12]=[CH:13][C:14]([Cl:16])=[CH:15][C:10]=3[Cl:9])[N:18]=2)=[O:31])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 2899CycloheptylamineHCID 10179718HCID 10179718, compound

Product 1

HCID 10116471HCID 10116471, compound

Procedure

Using essentially the same procedure as Example 36, Step B (Method B), but using neat cycloheptylamine (1.5 mL), ethyl 4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1-methylimidazole-2-carboxylate (30 mg, 0.073 mmol) was converted to the title compound after purification by Prep TLC (25% ethyl acetate in hexanes).

Sources & evidence

ORD record
ord-c95b75085f5a49ee8fe5a79c29e851c9
Source dataset
uspto-grants-2009_08
Patent number
US07572785B2

Reaction notes

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