Cyclopentylamine → HCID 10275599, compound

HRID 2101728Notes

Reaction equation

HRID 2101728 reaction equation
[CH:1]1([NH2:6])[CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:7][C:8]1[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:9]=1[C:15]1[N:16]=[C:17]([C:28](OCC)=[O:29])[N:18]([CH3:27])[C:19]=1[C:20]1[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=1>>[CH:1]1([NH:6][C:28]([C:17]2[N:18]([CH3:27])[C:19]([C:20]3[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=3)=[C:15]([C:9]3[CH:10]=[CH:11][C:12]([Cl:14])=[CH:13][C:8]=3[Cl:7])[N:16]=2)=[O:29])[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 2906CyclopentylamineHCID 10179718HCID 10179718, compound

Product 1

HCID 10275599HCID 10275599, compound

Procedure

Using essentially the same procedure as Example 36, Step B (Method B), but using neat cyclopentylamine (1.5 mL), ethyl 4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1-methylimidazole-2-carboxylate (30 mg, 0.073 mmol) was converted to the title compound after purification by Prep TLC (25% ethyl acetate in hexanes).

Sources & evidence

ORD record
ord-43941d5d536b4315a24df3e59b0a230f
Source dataset
uspto-grants-2009_08
Patent number
US07572785B2

Reaction notes

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