Cyclohexylamine → HCID 10227474, compound

HRID 2101732Notes

Reaction equation

HRID 2101732 reaction equation
[CH:1]1([NH2:7])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:16]=[C:17]([C:30](OCC)=[O:31])[N:18]([CH2:28][CH3:29])[C:19]=2[C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][C:21]=2[Cl:27])=[CH:11][CH:10]=1>>[CH:1]1([NH:7][C:30]([C:17]2[N:18]([CH2:28][CH3:29])[C:19]([C:20]3[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][C:21]=3[Cl:27])=[C:15]([C:12]3[CH:11]=[CH:10][C:9]([Cl:8])=[CH:14][CH:13]=3)[N:16]=2)=[O:31])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 7965CyclohexylamineHCID 22066065HCID 22066065, compound

Product 1

HCID 10227474HCID 10227474, compound

Procedure

Using essentially the same procedure as Example 42, Step C, but using neat cyclohexylamine (2 mL), ethyl 4-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-1-ethylimidazole-2-carboxylate (30 mg, 0.073 mmol) from Example 42, Step B was converted to the title compound after purification by Prep TLC (25% ethyl acetate in hexanes).

Sources & evidence

ORD record
ord-ef07424dff634bbfb86a929fa7320489
Source dataset
uspto-grants-2009_08
Patent number
US07572785B2

Reaction notes

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