Lithium Hydroxide → HCID 25055750, compound

Participants

Reaction Steps

To a stirred solution of 3.2 (0.0313 g, 0.062 mmol) in THF (2.00 mL) and EtOH (2.00 mL) at 23° C. was added 1N lithium hydroxide (2.00 mL, 2.00 mmol). Stirring continued for 20 hours. The reaction mixture was concentrated in vacuo, 1N HCl was added to reach pH 1, and the resulting mixture was extracted with EtOAc (3×10 mL), dried over MgSO4 and concentrated in vacuo. The residue was then purified by flash chromatography (SiO2 gel 60, eluted with 0%-20% EtOAc in hexanes) to give a clear oil (0.0241 g, 82% yield). 1H NMR (400 MHz, CDCl3) δ ppm 7.58 (I H, d, J=8.2 Hz), 7.40 (1H, dd, J=8.4, 2.2 Hz), 7.13 (2H, d, J=8.6 Hz), 7.08 (1H, d, J=1.5 Hz), 7.00 (1H, t, J=8.6 Hz), 6.92 (2H, d, J=8.6 Hz), 6.86 (1H, m), 6.79 (1H, m), 5.57 (1H, m), 5.50 (1H, m), 4.99 (2H, s), 3.79 (3H, s), 3.76 (1H, dd, J=14.5, 7.8 Hz), 2.71 (2H, dd, J=7.8, 2.3 Hz), 1.66 (3H, d, J=6.3 Hz), 1.23 (9H, m). MS ESI (neg.) m/e: 951.4 (2M−H)+, 475.1 (M−H)+.

Provenance & Evidence