HCID 57672428, compound → HCID 57672375, compound

HRID 2101757Notes

Reaction equation

HRID 2101757 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([CH2:14][CH2:15][CH3:16])[CH2:9][C:10]([O:12][CH3:13])=[O:11])=[CH:4][CH:3]=1.Cl[CH2:18][C:19]1[CH:20]=[CH:21][C:22]([C:34]([CH3:37])([CH3:36])[CH3:35])=[C:23]([C:25]2[CH:30]=[C:29]([O:31][CH3:32])[CH:28]=[CH:27][C:26]=2[F:33])[CH:24]=1>>[CH3:37][C:34]([C:22]1[C:23]([C:25]2[CH:30]=[C:29]([O:31][CH3:32])[CH:28]=[CH:27][C:26]=2[F:33])=[CH:24][C:19]([CH2:18][O:1][C:2]2[CH:3]=[CH:4][C:5]([C@@H:8]([CH2:14][CH2:15][CH3:16])[CH2:9][C:10]([O:12][CH3:13])=[O:11])=[CH:6][CH:7]=2)=[CH:20][CH:21]=1)([CH3:35])[CH3:36]

Participants

3

Reactant 2

HCID 57672428HCID 57672428, compoundHCID 57801814HCID 57801814, compound

Product 1

HCID 57672375HCID 57672375, compoundYield 50.7%

Procedure

Compound 7.1 (0.051 g, 0.2 mmol) was alkylated by reaction with compound A (0.08 g, 0.3 mmol) according to the method given in Example 1 to give compound 7.2 as a clear oil (0.05 g, 44% yield). MS ESI (pos.) m/e: 515.2 (M+Na)+, 510.2 (M+H2O)+.

Sources & evidence

ORD record
ord-fa89ab2e3abb40a1b14a4dc90bb5510d
Source dataset
uspto-grants-2009_08
Patent number
US07572934B2

Reaction notes

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