Cesium carbonate → Ethyl (3S,4E)-3-(4-(((2'-(butyloxy)-6-(1,1-dimethylethyl)-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)-4-hexenoate

Participants

Reaction Conditions

Reaction Steps

A mixture of compound B (11 mg, 47 μmol), compound C (17 mg, 47 μmol), and cesium carbonate (23 mg, 70 μmol) in DMF (1.0 mL) was stirred for 16 hours at 23° C. The mixture was diluted with EtOAc, washed with water and brine, dried over MgSO4, and concentrated. The crude product was purified by silica gel flash chromatography (0-10% EtOAc/hexane) to afford compound 11.1 (21 mg, 81% yield) as a colorless oil. MS ESI (pos.) m/e: 576 (M+H2O), 581 (M+Na).

Provenance & Evidence