Lithium Hydroxide → HCID 57672496, compound

Participants

Reaction Steps

The reaction mixture of compound A (30.0 mg, 97.8 μmol), compound 12.3 (22.4 mg, 108 μmol) and cesium carbonate (38.2 mg, 117 μmol) in DMF (1.0 mL) was stirred at room temperature overnight. The resulting reaction mixture was treated with lithium hydroxide (23.4 mg, 978 μmol) in water (0.5 mL), and stirred at room temperature for 5 hours. The reaction mixture was purified by reverse phase preparative HPLC to give the title compound. MS ESI (neg.) m/e: 449 (M−H). 1H NMR (CD3CN) δ 7.61(d, 1H), 7.41(d, 1H), 7.11(d, 2H), 7.06(m, 2H), 6.93(m, 1H), 6.89(d, 2H), 6.81(d, 1H), 5.02(s, 2H), 3.77 (s, 3H), 2.86(dd, 1H), 2.63(m, 2H), 1.21(s, 9H), 1.09(d, 3H).

Provenance & Evidence