Ethanol → HCID 25056273, compound

Participants

Reaction Steps

To a stirred solution of 15.6 (0.044 g, 0.087 mmol) in EtOH (2.00 mL, 0.087 mmol) and THF (2.00 mL, 0.087 mmol) at 23° C. was added a solution of 1M sodium hydroxide (1.00 mL, 1.0 mmol). Stirring was continued for 18 hours. The resulting reaction was concentrated in vacuo. 1N HCl was added to pH 1, the resulting mixture was extracted EtOAc, dried over MgSO4, and concentrated. The crude product was purified by silica gel flash chromatography (0-20% EtOAc/hexane) to afford compound 15 (31 mg, 74% yield) as a colorless oil. MS ESI (neg.) m/e: 951.4 (2M−H)+, 475.1 (M−H)+.

Provenance & Evidence