Ethanol → HCID 25056532, compound

Participants

Reaction Steps

To a stirred solution of 17.2 (0.048 g, 0.095 mmol) in EtOH (2.00 mL, 0.087 mmol) and THF (2.00 mL, 0.087 mmol) at 23° C. was added a solution of 1 M sodium hydroxide (1.00 mL, 1.0 mmol). Stirring was continued for 18 hours. The resulting reaction was concentrated in vacuo. 1 N HCl was added to bring the pH to 1, and the resulting mixture was extracted with EtOAc, dried over MgSO4, and concentrated. The crude product was purified by silica gel flash chromatography (0-20% EtOAc/hexane) to afford compound 17 (36 mg, 79% yield) as a colorless oil. MS ESI (neg.) m/e: 475.1 (M−H)+.

Provenance & Evidence