Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → HCID 57672372, compound

Participants

Reaction Steps

To a stirred solution of 18.1 (180 mg, 0.57 mmol) in EtOH (5 mL) at 23 C was added PPTS (catalytic). Stirring was continued for 16 hours. The reaction was concentrated in vacuo. The residue was then purified by flash chromatography (SiO2 gel 60, eluted with 0 to 20% EtOAc in hexanes). Fractions containing the desired product were combined and concentrated to give a colorless oil. The residue was purified by flash chromatography (SiO2 gel 60, eluted with 0 to 20% EtOAc in hexanes). The combined fractions were concentrated under reduced pressure to afford phenol 18.2 (120 mg, 89%) as a colorless oil.

Provenance & Evidence