Ethanol → HCID 25056790, compound

Participants

Reaction Steps

To a stirred solution of 24.3 (0.050 g, 0.10 mmol) in THF (2 mL, 0.2 mmol) and EtOH (2 mL, 0.2 mmol) at 23° C. was added a solution of 1 M sodium hydroxide (1.00 mL, 1.0 mmol). The resulting mixture was stirred for 18 hours. The resulting mixture was then concentrated in vacuo. 1 N HCl was added to bring the pH to 1, and the resulting mixture was extracted with EtOAc, dried over MgSO4, filtered, and concentrated. The product was purified by silica gel flash chromatography (0-20% EtOAc/hexane) to afford compound 24 (28 mg, 57% yield) as a colorless oil. MS ESI (neg.) m/e: 487.1 (M−H)+.

Provenance & Evidence