HCID 57672522, compound → HCID 57672404, compound

Participants

Reaction Steps

To a flask containing 27.3 (0.4140 g, 1.268 mmol) under an atmosphere of nitrogen was added 10% Pd/C (0.20 g, 1.88 mmol). The flask was sealed with a rubber septum. To this system was added EtOAc (10 mL) and then vacuum was applied followed by addition of H2 gas (this was repeated three times). A balloon was placed on the flask and the reaction was stirred under H2 overnight. The reaction was filtered, concentrated, and purified by silica gel chromatography (0 to 20% EtOAc/hexanes) to afford a 27.4 (0.102 g, 34% yield).

Provenance & Evidence