Lithium Hydroxide → HCID 25056792, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 27.5 (0.039 g, 0.076 mmol) in THF/MeOH (2/1) (1.5 mL) was added LiOH (0.50 mL, 0.50 mmol). The resulting mixture was stirred overnight at 23° C., quenched with excess 1 N HCl, and extracted with EtOAc. The combined organic layers were dried over Na2SO4 and concentrated. The crude residue was purified by silica gel chromatography (0 to 40% EtOAc/hexanes) to afford a 27 (0.024 g, 64% yield). MS ESI (neg.) m/e: 491.2 (M−H)+.

Provenance & Evidence