Ethanol → HCID 25057312, compound

Participants

Reaction Steps

To a stirred solution of 30.1 (0.054 g, 0.11 mmol) in THF (2 mL, 0.2 mmol) and EtOH (2 mL, 0.2 mmol) at 23° C. was added a solution of 1 M sodium hydroxide (1.00 mL, 1.0 mmol). The resulting mixture was stirred for 19 hours. The reaction was then concentrated in vacuo, and 1 N HCl was added to bring the pH to 1. The resulting mixture was extracted with EtOAc, dried over MgSO4, filtered, and concentrated. The resulting product was purified by silica gel flash chromatography (0-20% EtOAc/hexane) to afford compound 30 (40 mg, 76% yield) as a colorless oil. MS ESI (neg.) m/e: 983.5 (2M−H)+, 491.2 (M−H)+.

Provenance & Evidence