Ethanol → HCID 25057560, compound

Participants

Reaction Steps

To a stirred solution of 42.3 (0.048 g, 0.09 mmol) in THF (2 mL, 0.2 mmol) and EtOH (2 mL, 0.2 mmol) at 23° C. was added a solution of 1 M sodium hydroxide (1.00 mL, 1.0 mmol). The resulting mixture was stirred for 21 hours and then concentrated in vacuo. 1 N HCl was added to bring the pH to 1, and the resulting mixture was extracted with EtOAc, dried over MgSO4, filtered, and concentrated. The product was purified by silica gel flash chromatography (0-20% EtOAc/hexane) to afford compound 42 (33 mg, 73% yield) as a colorless oil. MS ESI (neg.) m/e: 511.3 (M−H)+.

Provenance & Evidence