Lithium Hydroxide → HCID 42608568, compound

Participants

Reaction Steps

A reaction mixture of 43.2 (32.0 mg, 61 μmol) and lithium hydroxide (0.2 mL, 3.33M in water) in MeOH (1.0 mL) was stirred at ambient temperature for 16 hours. The reaction mixture was purified by HPLC (reverse phase) to give the title compound 43. 1H NMR (400 MHz, CD3CN) δ ppm 1.16 (s, 9H) 1.19-1.36 (m, 1H) 1.45-1.67 (m, 1H) 2.45 (d, J=8.61 Hz, 1H) 2.53 (d, J=6.65 Hz, 1H) 3.14 (s, 3H) 3.20 (t, J=6.46 Hz, 2H) 3.72 (s, 3H) 4.97 (s, 2H) 6.77 (dd, J=6.26, 3.13 Hz, 1H) 6.83-6.91 (m, 3H) 6.99-7.10 (m, 4H) 7.37 (dd, J=8.22, 1.96 Hz, 1H) 7.57 (d, J=8.22 Hz, 1H). MS ESI (neg.) m/e: 507.2 (M−H)+.

Provenance & Evidence