Ethyl Acetate → HCID 57672532, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of (R)-ethyl 3-(4-hydroxyphenyl)-5-methylhex-4-enoate 14.2 (0.200 g, 0.8 mmol) in EtOAc (5 mL, 51 mmol) at 0° C. was added Pd/C (0.09 g, 0.8 mmol). See Example 14—it is possible that 14.3 is the R enantiomer and that 14.2 is the S enantiomer although it is believed that 14.2 is the enantiomer shown. The reaction mixture was placed under an atmosphere of hydrogen and stirred at 23° C. for 2 hours. The reaction mixture was filtered and concentrated in vacuo. The resulting product was purified by silica gel flash chromatography (0-20% EtOAc/hexane) to afford (S)-ethyl 3-(4-hydroxyphenyl)-5-methylhexanoate 45.1 (0.200 g, 99% yield) as a colorless oil.

Provenance & Evidence