HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → Methyl [4-chloro-5-cyano-2-(difluoromethyl)-1H-indol-1-yl]acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Methyl bromoacetate | HCID 60984 | — |
| Reactant | 4-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrile | HCID 24985632 | — |
| Product | Methyl [4-chloro-5-cyano-2-(difluoromethyl)-1H-indol-1-yl]acetate | HCID 24985637 | — |
Reaction Steps
Synthesized as described in Example 4 using 4-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrile, methyl bromoacetate (2 eq) and Cs2CO3 (2 eq): MS (ES) m/z 299 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07572820B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-6f1dad82feda47b4abee301566820e53 |
| Source note | uspto-grants-2009_08 |