Cesium carbonate → HCID 57800302, compound

HRID 2101840Notes

Reaction equation

[Cl:1][C:2]1[C:10]([C:11]#[N:12])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH:13]([F:15])[F:14])[NH:6]2.Br[CH2:17][C:18]([NH2:20])=[O:19].C([O-])([O-])=O.[Cs+].[Cs+]>>[Cl:1][C:2]1[C:10]([C:11]#[N:12])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH:13]([F:14])[F:15])[N:6]2[CH2:17][C:18]([NH2:20])=[O:19]

Participants

Reactant 3

HCID 10796Cesium carbonate

HCID 696322-Bromoacetamide

HCID 249856324-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrile

Product 1

HCID 57800302HCID 57800302, compound

Procedure

Synthesized as described in Example 4 using 4-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrile, bromoacetamide (2 eq) and Cs2CO3 (2 eq): MS (ES) m/z 284 (M+1).

Workup

customSynthesized

Sources & evidence

ORD record: ord-05fb07f56ac741be9e8c28e617c7a99e
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07572820B2

Reaction notes

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