Cesium carbonate → HCID 57800183, compound

HRID 2101842Notes

Reaction equation

HRID 2101842 reaction equation
[Cl:1][C:2]1[C:10]([C:11]#[N:12])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH:13]([F:15])[F:14])[NH:6]2.[C:16]([O:20][C:21](=[O:25])[CH:22](Br)[CH3:23])([CH3:19])([CH3:18])[CH3:17].C([O-])([O-])=O.[Cs+].[Cs+]>>[Cl:1][C:2]1[C:10]([C:11]#[N:12])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH:13]([F:14])[F:15])[N:6]2[CH:22]([CH3:23])[C:21]([O:20][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:25]

Participants

4

Reactant 3

HCID 10796Cesium carbonateHCID 545327tert-Butyl 2-bromopropanoateHCID 249856324-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrile

Product 1

HCID 57800183HCID 57800183, compound

Procedure

Synthesized as described in Example 4 using 4-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrile, 2-bromopropionic acid t-butyl ester (1.5 eq) and Cs2CO3 (1.5 eq): MS (ES) m/z 355 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-f3c2d6d6ed5f4dc187b609e8fa94df50
Source dataset
uspto-grants-2009_08
Patent number
US07572820B2

Reaction notes

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