4-(Chloromethyl)-1,3-thiazole → HCID 24985967, compound

HRID 2101852Notes

Reaction equation

HRID 2101852 reaction equation
[Cl:1][C:2]1[C:10]([C:11]#[N:12])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH:13]([F:15])[F:14])[NH:6]2.Cl[CH2:17][C:18]1[N:19]=[CH:20][S:21][CH:22]=1>>[Cl:1][C:2]1[C:10]([C:11]#[N:12])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH:13]([F:14])[F:15])[N:6]2[CH2:17][C:18]1[N:19]=[CH:20][S:21][CH:22]=1

Participants

3

Reactant 2

HCID 27632904-(Chloromethyl)-1,3-thiazoleHCID 249856324-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrile

Product 1

HCID 24985967HCID 24985967, compound

Procedure

Synthesized as described in Example 39 from 4-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrile and 4-(chloromethyl)-1,3-thiazole: MS (ESI) m/z 324 (M+1)

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-96f29b925a784a5d8ab329a9262b58e2
Source dataset
uspto-grants-2009_08
Patent number
US07572820B2

Reaction notes

Loading…