4-Chloro-3-(trifluoromethyl)benzoic acid → HCID 24984142, compound

Participants

Reaction Steps

4-Chloro-3-(trifluoromethyl)benzoic acid (0.016 g, 0.071 mmol) and CDl (0.012 g, 0.071 mmol) were combined in in CH3CN (3 mL). 2-[5-Cyano-4-(trifluoromethyl)-1H-indol-1-yl]-N-hydroxyethanimidamide (0.020 g, 0.071 mmol) was added after 5 min. After stirring at rt for 1 h, the reaction was heated at 150° C. in a microwave for 10 min. Purification (SiO2, EtOAc/hexanes) afforded the title compound (0.022 g): MS (ESI): m/z 471 (M+1).

Provenance & Evidence