4-(Trifluoromethoxy)benzoic acid → HCID 24984299, compound

HRID 2101891Notes

Reaction equation

HRID 2101891 reaction equation
[C:1]([C:3]1[C:4]([C:17]([F:20])([F:19])[F:18])=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:12][C:13](=[NH:16])[NH:14][OH:15])[CH:7]=[CH:6]2)#[N:2].[F:21][C:22]([F:34])([F:33])[O:23][C:24]1[CH:32]=[CH:31][C:27]([C:28](O)=O)=[CH:26][CH:25]=1>>[F:18][C:17]([F:19])([F:20])[C:4]1[C:3]([C:1]#[N:2])=[CH:11][CH:10]=[C:9]2[C:5]=1[CH:6]=[CH:7][N:8]2[CH2:12][C:13]1[N:16]=[C:28]([C:27]2[CH:31]=[CH:32][C:24]([O:23][C:22]([F:21])([F:33])[F:34])=[CH:25][CH:26]=2)[O:15][N:14]=1

Participants

3

Reactant 2

HCID 676134-(Trifluoromethoxy)benzoic acidHCID 178509476HCID 178509476, compound

Product 1

HCID 24984299HCID 24984299, compound

Procedure

Synthesized as described in Example 72 from 2-[5-cyano-4-(trifluoromethyl)-1H-indol-1-yl]-N-hydroxyethanimidamide and 4-[(trifluoromethyl)oxy]benzoic acid: MS (ESI): m/z 453 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-70715d8574344173a5cef552883c33bb
Source dataset
uspto-grants-2009_08
Patent number
US07572820B2

Reaction notes

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