4-(Chloromethyl)-1,3-thiazole hydrochloride → HCID 24984454, compound

HRID 2101899Notes

Reaction equation

HRID 2101899 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]1[C:11]([C:12]#[N:13])=[CH:10][CH:9]=[C:8]2[C:4]=1[CH:5]=[CH:6][NH:7]2.Cl.Cl[CH2:18][C:19]1[N:20]=[CH:21][S:22][CH:23]=1>>[S:22]1[CH:23]=[C:19]([CH2:18][N:7]2[C:8]3[C:4](=[C:3]([C:2]([F:14])([F:1])[F:15])[C:11]([C:12]#[N:13])=[CH:10][CH:9]=3)[CH:5]=[CH:6]2)[N:20]=[CH:21]1

Participants

3

Reactant 2

HCID 27632894-(Chloromethyl)-1,3-thiazole hydrochlorideHCID 674054494-(trifluoromethyl)-1H-indole-5-carbonitrile

Product 1

HCID 24984454HCID 24984454, compound

Procedure

Synthesized as described in Example 23 using 4-(trifluoromethyl)-1H-indole-5-carbonitrile and 4-(chloromethyl)-1,3-thiazole hydrochloride: MS (ES) m/z 308 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-5dcdf08512ed49219cb4c1050b921f40
Source dataset
uspto-grants-2009_08
Patent number
US07572820B2

Reaction notes

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