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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2101914Generated: November 1, 2026

4-Methyl-1,2,3-thiadiazole-5-carbohydrazide → 1-{[5-(4-Methyl-1,2,3-thiadiazol-5-yl)-1,3,4-oxadiazol-2-yl]methyl}-4-(trifluoromethyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/2101914

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methyl-1,2,3-thiadiazole-5-carbohydrazideHCID 1419752—
Reactant[5-cyano-4-(trifluoromethyl)-1H-indol-1-yl]acetic acidHCID 57800132—
Product1-{[5-(4-Methyl-1,2,3-thiadiazol-5-yl)-1,3,4-oxadiazol-2-yl]methyl}-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 57800159—

Reaction Steps

Synthesized as described in Example 35C from [5-cyano-4-(trifluoromethyl)-1H-indol-1-yl]acetic acid and 4-methyl-1,2,3-thiadiazole-5-carbohydrazide: MS (ES) m/z 391 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07572820B2
Source datasetuspto-grants-2009_08
ORD IDord-ee8d90052bd84872a9e9fa12e76fa027
Source noteuspto-grants-2009_08