2-(Bromomethyl)-5-(trifluoromethyl)furan → HCID 86620666, compound

HRID 2101945Notes

Reaction equation

HRID 2101945 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[C:8]([C:11]([F:14])([F:13])[F:12])[C:7]([C:15]#[N:16])=[CH:6][CH:5]=2.Br[CH2:18][C:19]1[O:20][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:22][CH:23]=1>>[CH3:1][C:2]1[N:3]([CH2:18][C:19]2[O:20][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:22][CH:23]=2)[C:4]2[C:9]([CH:10]=1)=[C:8]([C:11]([F:12])([F:14])[F:13])[C:7]([C:15]#[N:16])=[CH:6][CH:5]=2

Participants

3

Reactant 2

HCID 27946052-(Bromomethyl)-5-(trifluoromethyl)furanHCID 533093462-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

Product 1

HCID 86620666HCID 86620666, compound

Procedure

Synthesized as described in Example 4 using 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile and 2-(bromomethyl)-5-(trifluoromethyl)furan: 1H NMR (400 MHz, CDCl3) δ 7.54 (d, J=8.6 Hz, 1H), 7.51 (d, J=8.6 Hz, 1H), 6.70 (d, J=2.9 Hz, 1H), 6.63 (s, 1H), 6.11 (d, J=2.9 Hz, 1H), 5.32 (s, 2H), 2.55 (s, 3H); MS (ES) m/z 373 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-16a8a69d9bec4cca89888c48d2b4b752
Source dataset
uspto-grants-2009_08
Patent number
US07572820B2

Reaction notes

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