Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
6-(Trifluoromethyl)nicotinohydrazide → 2-Methyl-4-(trifluoromethyl)-1-({5-[6-(trifluoromethyl)-3-pyridinyl]-1,3,4-oxadiazol-2-yl}methyl)-1H-indole-5-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 6-(Trifluoromethyl)nicotinohydrazide | HCID 2777553 | — |
| 반응물 | [5-cyano-2-methyl-4-(trifluoromethyl)-1H-indol-1-yl]acetic acid | HCID 67404858 | — |
| 생성물 | 2-Methyl-4-(trifluoromethyl)-1-({5-[6-(trifluoromethyl)-3-pyridinyl]-1,3,4-oxadiazol-2-yl}methyl)-1H-indole-5-carbonitrile | HCID 86620669 | — |
반응 단계
Synthesized as described in Example 35C using [5-cyano-2-methyl-4-(trifluoromethyl)-1H-indol-1-yl]acetic acid and 6-(trifluoromethyl)-3-pyridinecarbohydrazide: 1H NMR (400 MHz, DMSO-d6) δ 9.27 (s, 1H), 8.54 (d, J=8.3 Hz, 1H), 8.11 (d, J=8.3 Hz, 1H), 8.08 (d, J=8.3 Hz, 1H), 7.78 (d, J=8.3 Hz, 1H), 6.66 (s, 1H), 6.03 (s, 2H), 2.58 (s, 3H); MS (ES) m/z 474 (M+Na).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07572820B2 |
| 출처 데이터셋 | uspto-grants-2009_08 |
| ORD ID | ord-3fe594d756ab4f1ea1d0cb56857242dc |
| 출처 메모 | uspto-grants-2009_08 |